Cation-coupled Chloride cotransporters
REACTOME PATHWAYThe Cation-coupled Chloride cotransporters pathway (Reactome ID: R-HSA-426117) involves 4 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Cation-coupled Chloride cotransporters
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bumetanide | — | 299 |
| 2 | Furosemide | — | 298 |
| 3 | Calcimycin | — | 216 |
| 4 | Hexachlorophene | — | 300 |
| 5 | Clotrimazole | — | 296 |
| 6 | triflupromazine hydrochloride | — | 12 |
| 7 | Metolazone | — | 166 |
About the Cation-coupled Chloride cotransporters Pathway
The Cation-coupled Chloride cotransporters pathway is catalogued in Reactome (ID: R-HSA-426117) and involves 4 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SLC12A1, SLC12A2, SLC12A3, SLC12A5.