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Metolazone

A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.

166+ PubMed studies analyzed · 11 RCTs · Evidence Score: 49.8

Research Domains

Metolazone has been studied across 12 research domains including ❤️ Cardiovascular, 🫘 Kidney, 🔥 Metabolic, 🦴 Bone & Joint, 🫁 Liver & Detox. The primary research focus is ❤️ Cardiovascular with 45% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Metolazone, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Chlorthalidone
11 shared targets
Indapamide
14 shared targets
stx64
13 shared targets
benzolamide
11 shared targets
Bumetanide
14 shared targets
Mafenide
9 shared targets
Zonisamide
11 shared targets
24
9 shared targets
trichlormethiazide
9 shared targets
trientine
9 shared targets
Loading evidence profile...

This evidence profile for Metolazone is generated deterministically from 166 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.