Question 1

What compounds affect the Unblocking of NMDA receptors, glutamate binding and activation pathway?

Accepted Answer

30 compounds in the BiohacksAI corpus have documented interactions with genes in the Unblocking of NMDA receptors, glutamate binding and activation pathway (Reactome ID: R-HSA-438066). These compounds target 10 genes within this pathway.

Question 2

What genes are in the Unblocking of NMDA receptors, glutamate binding and activation pathway?

Accepted Answer

The Unblocking of NMDA receptors, glutamate binding and activation pathway involves 10 genes. Key genes include: CAMK2B, CAMK2D, GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C.

#	Compound	Targets Hit	Studies
1	Glutamic Acid	—	297
2	Glutamic Acid	—	300
3	Glycine	—	300
4	pentamidine	—	299
5	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
6	Dextrorphan Dextro form of levorphanol. It acts as	—	300
7	Levorphanol	—	297
8	cycloserine	—	298
9	Aspartic Acid	—	300
10	D-Aspartic Acid	—	29
11	Ethidium	—	300
12	Dextrothyroxine	—	134
13	Dizocilpine Maleate	—	300
14	Ibotenic Acid	—	300
15	Spermine	—	300
16	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	—	300
17	aniracetam	—	110
18	Piracetam	—	300
19	eliprodil	—	33
20	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
21	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
22	sp600125	—	117
23	Kynurenic Acid	—	300
24	Phenformin	—	300
25	Carvedilol	—	296
26	Ibogaine	—	300
27	Riluzole	—	298
28	Quercetin	—	300
29	Sorafenib	—	300
30	alsterpaullone	—	12

BiohacksAI

Unblocking of NMDA receptors, glutamate binding and activation

Genes in this Pathway

Compounds Affecting Unblocking of NMDA receptors, glutamate binding and activation

About the Unblocking of NMDA receptors, glutamate binding and activation Pathway