Question 1

What compounds affect the Ras activation upon Ca2+ influx through NMDA receptor pathway?

Accepted Answer

25 compounds in the BiohacksAI corpus have documented interactions with genes in the Ras activation upon Ca2+ influx through NMDA receptor pathway (Reactome ID: R-HSA-442982). These compounds target 4 genes within this pathway.

Question 2

What genes are in the Ras activation upon Ca2+ influx through NMDA receptor pathway?

Accepted Answer

The Ras activation upon Ca2+ influx through NMDA receptor pathway involves 4 genes. Key genes include: CAMK2B, CAMK2D, GRIN1, GRIN2B.

#	Compound	Targets Hit	Studies
1	Glutamic Acid	—	297
2	Glutamic Acid	—	300
3	Glycine	—	300
4	pentamidine	—	299
5	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
6	Dextrorphan Dextro form of levorphanol. It acts as	—	300
7	Levorphanol	—	297
8	cycloserine	—	298
9	Aspartic Acid	—	300
10	eliprodil	—	33
11	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
12	D-Aspartic Acid	—	29
13	Ethidium	—	300
14	Dextrothyroxine	—	134
15	Dizocilpine Maleate	—	300
16	Ibotenic Acid	—	300
17	Spermine	—	300
18	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
19	sp600125	—	117
20	Kynurenic Acid	—	300
21	Phenformin	—	300
22	Carvedilol	—	296
23	Quercetin	—	300
24	Sorafenib	—	300
25	alsterpaullone	—	12

BiohacksAI

Ras activation upon Ca2+ influx through NMDA receptor

Genes in this Pathway

Compounds Affecting Ras activation upon Ca2+ influx through NMDA receptor

About the Ras activation upon Ca2+ influx through NMDA receptor Pathway