Interconversion of nucleotide di- and triphosphates
REACTOME PATHWAYThe Interconversion of nucleotide di- and triphosphates pathway (Reactome ID: R-HSA-499943) involves 5 genes and is affected by 13 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Interconversion of nucleotide di- and triphosphates
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Thymidine Monophosphate 5-Thymidylic acid. | — | 202 |
| 2 | Gemcitabine | — | 300 |
| 3 | Clofarabine | — | 298 |
| 4 | Hydroxyurea | — | 300 |
| 5 | Pemetrexed | — | 299 |
| 6 | Fluorodeoxyuridylate 5-Fluoro-2'-deoxyuridylate. | — | 102 |
| 7 | Methotrexate | — | 289 |
| 8 | Capecitabine | — | 297 |
| 9 | Cytarabine | — | 297 |
| 10 | Trifluridine | — | 295 |
| 11 | Methylene Blue | — | 200 |
| 12 | Carmustine | — | 297 |
| 13 | Meloxicam | — | 299 |
About the Interconversion of nucleotide di- and triphosphates Pathway
The Interconversion of nucleotide di- and triphosphates pathway is catalogued in Reactome (ID: R-HSA-499943) and involves 5 genes. In the BiohacksAI corpus, 13 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DTYMK, GSR, RRM1, RRM2, TYMS.