Uptake and function of anthrax toxins
REACTOME PATHWAYThe Uptake and function of anthrax toxins pathway (Reactome ID: R-HSA-5210891) involves 5 genes and is affected by 11 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Uptake and function of anthrax toxins
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Vemurafenib | — | 298 |
| 2 | trametinib | — | 296 |
| 3 | pd98059 | — | 7 |
| 4 | Dasatinib | — | 299 |
| 5 | Axitinib | — | 298 |
| 6 | arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from | — | 300 |
| 7 | Sorafenib | — | 300 |
| 8 | Genistein | — | 300 |
| 9 | Diminazene | — | 300 |
| 10 | silver sulfadiazine | — | 299 |
| 11 | Crizotinib | — | 298 |
About the Uptake and function of anthrax toxins Pathway
The Uptake and function of anthrax toxins pathway is catalogued in Reactome (ID: R-HSA-5210891) and involves 5 genes. In the BiohacksAI corpus, 11 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FURIN, MAP2K1, MAP2K2, MAP2K3, MAP2K4.