What compounds affect the DNA methylation pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the DNA methylation pathway (Reactome ID: R-HSA-5334118). These compounds target 3 genes within this pathway.

What genes are in the DNA methylation pathway?

The DNA methylation pathway involves 3 genes. Key genes include: DNMT1, DNMT3B, UHRF1.

DNA methylation

REACTOME PATHWAY

Reactome: R-HSA-53341183 genes26 compounds

The DNA methylation pathway (Reactome ID: R-HSA-5334118) involves 3 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DNMT1 DNMT3B UHRF1

Compounds Affecting DNA methylation

#	Compound	Targets Hit	Studies
1	Cefixime	—	300
2	Azacitidine	—	298
3	Azacitidine	—	300
4	s adenosylhomocysteine	—	300
5	DEAD-box RNA Helicases	—	169
6	Thioctic Acid	—	298
7	Methylene Blue	—	200
8	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
9	Ethidium	—	300
10	Levodopa	—	297
11	Thioctic Acid	—	300
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	Demeclocycline	—	5
14	Didanosine	—	297
15	Dinitolmide	—	25
16	doxylamine succinate	—	35
17	Methyldopa	—	297
18	egcg	—	300
19	Oleic Acid	—	112
20	Anthralin	—	299
21	Carboxin	—	174
22	Cefdinir	—	298
23	Decitabine	—	298
24	Fluorometholone	—	299
25	Oxytetracycline	—	300
26	Uridine	—	300

About the DNA methylation Pathway

The DNA methylation pathway is catalogued in Reactome (ID: R-HSA-5334118) and involves 3 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DNMT1, DNMT3B, UHRF1.