BBSome-mediated cargo-targeting to cilium
REACTOME PATHWAYThe BBSome-mediated cargo-targeting to cilium pathway (Reactome ID: R-HSA-5620922) involves 3 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting BBSome-mediated cargo-targeting to cilium
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Somatostatin | — | 300 |
| 2 | Somatostatin-28 | — | 299 |
| 3 | Camptothecin | — | 300 |
| 4 | Octreotide | — | 300 |
| 5 | Sertraline | — | 1,000 |
| 6 | Thioridazine | — | 35 |
| 7 | Methylene Blue | — | 200 |
About the BBSome-mediated cargo-targeting to cilium Pathway
The BBSome-mediated cargo-targeting to cilium pathway is catalogued in Reactome (ID: R-HSA-5620922) and involves 3 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCT2, MCHR1, SSTR3.