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BiohacksAI

Evidence-Based Biohacking

Patent Pending

RHO GTPases activate IQGAPs

REACTOME PATHWAY
Reactome: R-HSA-562646719 genes12 compounds

The RHO GTPases activate IQGAPs pathway (Reactome ID: R-HSA-5626467) involves 19 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC42MEN1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBA8TUBAL3TUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TUBB8B

Compounds Affecting RHO GTPases activate IQGAPs

#CompoundTargets HitStudies
1Colchicine—300
2Nocodazole Nocodazole is—215
3Vincristine—299
4Noscapine—300
5Podophyllotoxin—14
6Demecolcine—246
7Maytansine—300
8vinblastine sulfate—81
9Vorinostat—299
10Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).—300
11Nitroblue Tetrazolium Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases,—300
12casin—10

About the RHO GTPases activate IQGAPs Pathway

The RHO GTPases activate IQGAPs pathway is catalogued in Reactome (ID: R-HSA-5626467) and involves 19 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC42, MEN1, TUBA1A, TUBA1B, TUBA1C.