APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
REACTOME PATHWAYThe APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway pathway (Reactome ID: R-HSA-5649702) involves 2 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Aurintricarboxylic Acid | — | 184 |
| 2 | Oleanolic Acid | — | 300 |
| 3 | stigmasterol | — | 300 |
| 4 | 4-Hydroxybenzoate-3-Monooxygenase | — | 300 |
| 5 | Ursolic Acid | — | 300 |
| 6 | Methyldopa | — | 297 |
| 7 | DEAD-box RNA Helicases | — | 169 |
| 8 | Thioctic Acid | — | 298 |
| 9 | egcg | — | 300 |
| 10 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 11 | Methylene Blue | — | 200 |
| 12 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 13 | Quercetin | — | 300 |
| 14 | Rosmarinic Acid | — | 300 |
| 15 | Rutin | — | 300 |
| 16 | Methotrexate | — | 289 |
| 17 | calycosin | — | 300 |
| 18 | Demeclocycline | — | 5 |
| 19 | Dequalinium | — | 46 |
| 20 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 21 | Hexachlorophene | — | 300 |
| 22 | Idarubicin | — | 299 |
| 23 | Oxytetracycline | — | 300 |
| 24 | piceatannol | — | 300 |
| 25 | Nitroprusside | — | 299 |
| 26 | sp600125 | — | 117 |
| 27 | Stavudine | — | 298 |
| 28 | streptonigrin | — | 299 |
| 29 | alphitonin [Supplementary Concept] from | — | 300 |
| 30 | Thioctic Acid | — | 300 |
| 31 | Isoniazid Antibacterial agent used primarily as | — | 299 |
About the APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Pathway
The APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway pathway is catalogued in Reactome (ID: R-HSA-5649702) and involves 2 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include OGG1, POLB.