Signaling by FGFR2 in disease
REACTOME PATHWAYThe Signaling by FGFR2 in disease pathway (Reactome ID: R-HSA-5655253) involves 4 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Signaling by FGFR2 in disease
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | pictilisib | — | 25 |
| 2 | Wortmannin | — | 300 |
| 3 | ly294002 | — | 11 |
| 4 | alpelisib | — | 227 |
| 5 | Sirolimus | — | 300 |
| 6 | torin 1 | — | 10 |
| 7 | Quercetin | — | 300 |
| 8 | Sorafenib | — | 300 |
| 9 | Axitinib | — | 298 |
| 10 | Dasatinib | — | 299 |
| 11 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 12 | Dactinomycin | — | 297 |
About the Signaling by FGFR2 in disease Pathway
The Signaling by FGFR2 in disease pathway is catalogued in Reactome (ID: R-HSA-5655253) and involves 4 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FGF22, FGFR2, GRB2, PIK3R1.