Josephin domain DUBs
REACTOME PATHWAYThe Josephin domain DUBs pathway (Reactome ID: R-HSA-5689877) involves 2 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Josephin domain DUBs
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Hexachlorophene | — | 300 |
| 2 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 3 | kenpaullone | — | 8 |
| 4 | Genistein | — | 300 |
| 5 | amn082 | — | 29 |
| 6 | Medroxyprogesterone Acetate | — | 299 |
| 7 | Nitrendipine | — | 299 |
| 8 | Oxytetracycline | — | 300 |
| 9 | egcg | — | 300 |
| 10 | Clotrimazole | — | 296 |
| 11 | Demeclocycline | — | 5 |
| 12 | Edaravone | — | 298 |
About the Josephin domain DUBs Pathway
The Josephin domain DUBs pathway is catalogued in Reactome (ID: R-HSA-5689877) and involves 2 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PRKN, VCP.