Highly calcium permeable nicotinic acetylcholine receptors
REACTOME PATHWAYThe Highly calcium permeable nicotinic acetylcholine receptors pathway (Reactome ID: R-HSA-629597) involves 2 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Highly calcium permeable nicotinic acetylcholine receptors
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Nicotine Nicotine is highly toxic alkaloid. It is | — | 298 |
| 2 | Mecamylamine | — | 298 |
| 3 | Lobeline | — | 300 |
| 4 | Dihydro-beta-Erythroidine Dihydro analog of beta-erythroidine, which is isolated from | — | 300 |
| 5 | Dimethylphenylpiperazinium Iodide | — | 33 |
| 6 | Arecoline | — | 299 |
| 7 | mg624 | — | 3 |
| 8 | Alcuronium | — | 300 |
| 9 | Anabasine | — | 300 |
| 10 | Ibogaine | — | 300 |
| 11 | Ondansetron | — | 299 |
| 12 | Pancuronium | — | 299 |
About the Highly calcium permeable nicotinic acetylcholine receptors Pathway
The Highly calcium permeable nicotinic acetylcholine receptors pathway is catalogued in Reactome (ID: R-HSA-629597) and involves 2 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHRNA1, CHRNA4.