What compounds affect the Neurexins and neuroligins pathway?

22 compounds in the BiohacksAI corpus have documented interactions with genes in the Neurexins and neuroligins pathway (Reactome ID: R-HSA-6794361). These compounds target 7 genes within this pathway.

What genes are in the Neurexins and neuroligins pathway?

The Neurexins and neuroligins pathway involves 7 genes. Key genes include: CASK, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRM1, GRM5.

Neurexins and neuroligins

REACTOME PATHWAY

Reactome: R-HSA-67943617 genes22 compounds

The Neurexins and neuroligins pathway (Reactome ID: R-HSA-6794361) involves 7 genes and is affected by 22 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASK GRIN1 GRIN2A GRIN2B GRIN2C GRM1 GRM5

Compounds Affecting Neurexins and neuroligins

#	Compound	Targets Hit	Studies
1	Glutamic Acid	—	297
2	Glutamic Acid	—	300
3	Ibotenic Acid	—	300
4	Glycine	—	300
5	pentamidine	—	299
6	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
7	Dextrorphan Dextro form of levorphanol. It acts as	—	300
8	Levorphanol	—	297
9	cycloserine	—	298
10	Aspartic Acid	—	300
11	D-Aspartic Acid	—	29
12	Ethidium	—	300
13	Dextrothyroxine	—	134
14	Dizocilpine Maleate	—	300
15	Spermine	—	300
16	eliprodil	—	33
17	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
18	Kynurenic Acid	—	300
19	Phenformin	—	300
20	Carvedilol	—	296
21	Ibogaine	—	300
22	Crizotinib	—	298

About the Neurexins and neuroligins Pathway

The Neurexins and neuroligins pathway is catalogued in Reactome (ID: R-HSA-6794361) and involves 7 genes. In the BiohacksAI corpus, 22 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASK, GRIN1, GRIN2A, GRIN2B, GRIN2C.