COPI-independent Golgi-to-ER retrograde traffic
REACTOME PATHWAYThe COPI-independent Golgi-to-ER retrograde traffic pathway (Reactome ID: R-HSA-6811436) involves 21 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting COPI-independent Golgi-to-ER retrograde traffic
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Colchicine | — | 300 |
| 2 | Nocodazole Nocodazole is | — | 215 |
| 3 | Vincristine | — | 299 |
| 4 | Noscapine | — | 300 |
| 5 | Podophyllotoxin | — | 14 |
| 6 | Demecolcine | — | 246 |
| 7 | Maytansine | — | 300 |
| 8 | vinblastine sulfate | — | 81 |
| 9 | Vorinostat | — | 299 |
| 10 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 11 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 12 | Ethidium | — | 300 |
| 13 | Oxytetracycline | — | 300 |
| 14 | urolithin d | — | 2 |
| 15 | Kaempferols | — | 300 |
| 16 | Nadolol | — | 297 |
| 17 | Myristic Acid | — | 300 |
About the COPI-independent Golgi-to-ER retrograde traffic Pathway
The COPI-independent Golgi-to-ER retrograde traffic pathway is catalogued in Reactome (ID: R-HSA-6811436) and involves 21 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GALNT1, GALNT2, PAFAH1B2, PAFAH1B3, TUBA1A.