Mitotic Metaphase/Anaphase Transition
REACTOME PATHWAYThe Mitotic Metaphase/Anaphase Transition pathway (Reactome ID: R-HSA-68881) involves 1 genes and is affected by 13 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Mitotic Metaphase/Anaphase Transition
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | ly294002 | — | 11 |
| 2 | Wortmannin | — | 300 |
| 3 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 4 | Oleic Acid | — | 112 |
| 5 | Quercetin | — | 300 |
| 6 | Simvastatin | — | 1,000 |
| 7 | cefaclor | — | 299 |
| 8 | Disulfiram | — | 297 |
| 9 | Hexachlorophene | — | 300 |
| 10 | Lithocholic Acid | — | 300 |
| 11 | Nisoldipine | — | 297 |
| 12 | Oxyphenbutazone | — | 300 |
| 13 | Oxytetracycline | — | 300 |
About the Mitotic Metaphase/Anaphase Transition Pathway
The Mitotic Metaphase/Anaphase Transition pathway is catalogued in Reactome (ID: R-HSA-68881) and involves 1 genes. In the BiohacksAI corpus, 13 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PLK1.