What genes are in the Processive synthesis on the lagging strand pathway?

The Processive synthesis on the lagging strand pathway involves 3 genes. Key genes include: DNA2, FEN1, PCNA.

Processive synthesis on the lagging strand

Q: What compounds affect the Processive synthesis on the lagging strand pathway?

25 compounds in the BiohacksAI corpus have documented interactions with genes in the Processive synthesis on the lagging strand pathway (Reactome ID: R-HSA-69183). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-691833 genes25 compounds

The Processive synthesis on the lagging strand pathway (Reactome ID: R-HSA-69183) involves 3 genes and is affected by 25 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DNA2 FEN1 PCNA

Compounds Affecting Processive synthesis on the lagging strand

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Quercetin	—	300
3	Aurintricarboxylic Acid	—	184
4	Norepinephrine Precursor of epinephrine that is secreted by	—	298
5	Dequalinium	—	136
6	Diiodotyrosine	—	300
7	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
8	Epinephrine	—	299
9	Ethidium	—	300
10	Idarubicin	—	299
11	Levodopa	—	297
12	Methyldopa	—	297
13	piceatannol	—	300
14	Doxycycline	—	999
15	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
16	Methylene Blue	—	200
17	Carmine Coloring matter from	—	300
18	Cisplatin	—	300
19	Demeclocycline	—	297
20	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
21	Oxytetracycline	—	300
22	streptonigrin	—	299
23	Oleanolic Acid	—	300
24	Triiodothyronine	—	300
25	Uridine Triphosphate Uridine 5'-(tetrahydrogen triphosphate).	—	300

About the Processive synthesis on the lagging strand Pathway

The Processive synthesis on the lagging strand pathway is catalogued in Reactome (ID: R-HSA-69183) and involves 3 genes. In the BiohacksAI corpus, 25 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DNA2, FEN1, PCNA.