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Cisplatin

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

300+ PubMed studies analyzed · 2 RCTs · Evidence Score: 41.7

Research Domains

Cisplatin has been studied across 15 research domains including 🔬 Oncology, 🫘 Kidney, 🧬 Hormones, 🫁 Liver & Detox, 🔬 Inflammation. The primary research focus is 🔬 Oncology with 67% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Cisplatin, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Iodoacetamide
18 shared targets
Methyldopa
20 shared targets
Diamide
7 shared targets
tyrphostin
17 shared targets
Demeclocycline
7 shared targets
Aurintricarboxylic
21 shared targets
darapladib
8 shared targets
Emodin
18 shared targets
Methylergonovine
10 shared targets
Methysergide
11 shared targets
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This evidence profile for Cisplatin is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.