What compounds affect the Gluconeogenesis pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the Gluconeogenesis pathway (Reactome ID: R-HSA-70263). These compounds target 3 genes within this pathway.

What genes are in the Gluconeogenesis pathway?

The Gluconeogenesis pathway involves 3 genes. Key genes include: FBP1, GAPDH, PGAM1.

Gluconeogenesis

REACTOME PATHWAY

Reactome: R-HSA-702633 genes28 compounds

The Gluconeogenesis pathway (Reactome ID: R-HSA-70263) involves 3 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FBP1 GAPDH PGAM1

Compounds Affecting Gluconeogenesis

#	Compound	Targets Hit	Studies
1	Azacitidine	—	298
2	Azacitidine	—	300
3	Epinephrine	—	299
4	Berberine	—	300
5	plumbagin [Supplementary Concept]	—	300
6	Vitamin K 3	—	300
7	caffeic acid	—	300
8	Catechin	—	51
9	Rosmarinic Acid	—	300
10	Vitamin K 2	—	300
11	Carbazilquinone	—	48
12	salvin [Supplementary Concept]	—	300
13	Dactinomycin	—	297
14	Dihydroxyphenylalanine	—	300
15	Ergosterol	—	300
16	Ethidium	—	300
17	Fusaric Acid	—	300
18	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
19	Lovastatin	—	300
20	Methyldopa	—	297
21	Norepinephrine Precursor of epinephrine that is secreted by	—	298
22	Oxcarbazepine	—	296
23	Pioglitazone	—	297
24	streptonigrin	—	299
25	Adenosine Monophosphate Adenine nucleotide containing	—	300
26	Disulfiram	—	297
27	tyrphostin ag 1478	—	4
28	egcg	—	300

About the Gluconeogenesis Pathway

The Gluconeogenesis pathway is catalogued in Reactome (ID: R-HSA-70263) and involves 3 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FBP1, GAPDH, PGAM1.