Citric acid cycle (TCA cycle)
REACTOME PATHWAYThe Citric acid cycle (TCA cycle) pathway (Reactome ID: R-HSA-71403) involves 6 genes and is affected by 21 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Citric acid cycle (TCA cycle)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Suramin | — | 300 |
| 2 | Demeclocycline | — | 5 |
| 3 | Dinitrochlorobenzene | — | 300 |
| 4 | kenpaullone | — | 8 |
| 5 | Vorinostat | — | 299 |
| 6 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 7 | Disulfiram | — | 297 |
| 8 | Vanillic Acid | — | 300 |
| 9 | fisetin | — | 78 |
| 10 | Aurintricarboxylic Acid | — | 184 |
| 11 | Cisplatin | — | 300 |
| 12 | Iodoacetamide | — | 300 |
| 13 | piceatannol | — | 300 |
| 14 | egcg | — | 300 |
| 15 | Rutin | — | 300 |
| 16 | Oxaprozin | — | 181 |
| 17 | Pioglitazone | — | 297 |
| 18 | streptonigrin | — | 299 |
| 19 | 19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept] | — | 300 |
| 20 | triolimus [Supplementary Concept] | — | 33 |
| 21 | Sorafenib | — | 300 |
About the Citric acid cycle (TCA cycle) Pathway
The Citric acid cycle (TCA cycle) pathway is catalogued in Reactome (ID: R-HSA-71403) and involves 6 genes. In the BiohacksAI corpus, 21 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DLD, FH, FXN, MDH2, SIRT3.