What compounds affect the mRNA Splicing pathway?

17 compounds in the BiohacksAI corpus have documented interactions with genes in the mRNA Splicing pathway (Reactome ID: R-HSA-72172). These compounds target 4 genes within this pathway.

What genes are in the mRNA Splicing pathway?

The mRNA Splicing pathway involves 4 genes. Key genes include: HNRNPA1, HSPA8, PTBP1, SF3B3.

mRNA Splicing

REACTOME PATHWAY

Reactome: R-HSA-721724 genes17 compounds

The mRNA Splicing pathway (Reactome ID: R-HSA-72172) involves 4 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HNRNPA1 HSPA8 PTBP1 SF3B3

Compounds Affecting mRNA Splicing

#	Compound	Targets Hit	Studies
1	Azauridine	—	300
2	Carboxin	—	174
3	Digitoxin	—	300
4	Digoxin	—	299
5	Ethylenethiourea	—	300
6	Nadolol	—	297
7	Ouabain	—	300
8	streptonigrin	—	299
9	Sulfadiazine	—	298
10	Thioridazine	—	35
11	triflupromazine hydrochloride	—	12
12	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
13	Hexachlorophene	—	300
14	Ergosterol	—	300
15	Camptothecin	—	300
16	Quercetin	—	300
17	trichostatic acid [Supplementary Concept] related to trichostatin	—	300

About the mRNA Splicing Pathway

The mRNA Splicing pathway is catalogued in Reactome (ID: R-HSA-72172) and involves 4 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HNRNPA1, HSPA8, PTBP1, SF3B3.