What compounds affect the RNA Polymerase I Promoter Opening pathway?

23 compounds in the BiohacksAI corpus have documented interactions with genes in the RNA Polymerase I Promoter Opening pathway (Reactome ID: R-HSA-73728). These compounds target 2 genes within this pathway.

What genes are in the RNA Polymerase I Promoter Opening pathway?

The RNA Polymerase I Promoter Opening pathway involves 2 genes. Key genes include: MAPK3, MBD2.

RNA Polymerase I Promoter Opening

REACTOME PATHWAY

Reactome: R-HSA-737282 genes23 compounds

The RNA Polymerase I Promoter Opening pathway (Reactome ID: R-HSA-73728) involves 2 genes and is affected by 23 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

MAPK3 MBD2

Compounds Affecting RNA Polymerase I Promoter Opening

#	Compound	Targets Hit	Studies
1	DEAD-box RNA Helicases	—	169
2	Thioctic Acid	—	298
3	Methylene Blue	—	200
4	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
5	Cefixime	—	300
6	Ethidium	—	300
7	Levodopa	—	297
8	Thioctic Acid	—	300
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	Demeclocycline	—	5
11	Didanosine	—	297
12	Dinitolmide	—	25
13	Edaravone	—	298
14	Ribitol	—	297
15	Xylitol	—	300
16	plumbagin [Supplementary Concept]	—	300
17	pd98059	—	7
18	alsterpaullone	—	12
19	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
20	kenpaullone	—	8
21	Sorafenib	—	300
22	trametinib	—	296
23	withaferin	—	300

About the RNA Polymerase I Promoter Opening Pathway

The RNA Polymerase I Promoter Opening pathway is catalogued in Reactome (ID: R-HSA-73728) and involves 2 genes. In the BiohacksAI corpus, 23 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAPK3, MBD2.