What compounds target MAPK3?

BiohacksAI has identified 153 compounds that interact with MAPK3 (mitogen-activated protein kinase 3). Top compounds include: seliciclib, alvocidib, nelfinavir, zafirlukast, thioguanine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAPK3 (mitogen-activated protein kinase)?

MAPK3 is mitogen-activated protein kinase 3. It is a molecular target for 153 compounds documented in PubMed bioassay data. UniProt ID: P27361. NCBI Gene ID: 5595.

MAPK3

MOLECULAR TARGET

mitogen-activated protein kinase 3

UniProt: P27361 NCBI Gene: 5595153 compounds

MAPK3 (mitogen-activated protein kinase 3) is targeted by 153 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAPK3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	seliciclib	4.91	135
2	alvocidib	4.52	91
3	nelfinavir	4.51	90
4	zafirlukast	3.89	48
5	thioguanine	3.76	42
6	olomoucine	3.71	40
7	beta naphthoflavone	3.50	32
8	tae 684	3.43	30
9	hydroxyprogesterone	3.22	24
10	purvalanola	3.18	23
11	lestaurtinib	3.04	20
12	pf 03758309	3.00	19
13	hymenialdisine	3.00	19
14	carmofur	2.89	17
15	nalfurafine	2.77	15
16	tivozanib	2.64	13
17	ulixertinib	2.56	12
18	plumbagin [Supplementary Concept]	2.40	10
19	aloisine a	2.40	10
20	thimerosal	2.30	9
21	iodoquinol	2.20	8
22	ravoxertinib	2.08	7
23	purvalanol b	2.08	7
24	tanzisertib	1.95	6
25	tirilazad	1.79	5
26	pd98059	1.39	3
27	achyranthes bidentata	1.00	1
28	agastache rugosa	1.00	1
29	Garlic	1.00	1
30	allium tuberosum	1.00	1
31	aloe vera	1.00	1
32	apis mellifera	1.00	1
33	arctium lappa	1.00	1
34	Areca	1.00	1
35	artemisia argyi	1.00	1
36	artemisia capillaris	1.00	1
37	aster tataricus	1.00	1
38	atractylodes macrocephala	1.00	1
39	bombyx mori	1.00	1
40	bupleurum chinense	1.00	1
41	carthamus tinctorius	1.00	1
42	Centella	1.00	1
43	chaenomeles speciosa	1.00	1
44	citrus reticulata	1.00	1
45	crataegus pinnatifida	1.00	1
46	curculigo orchioides	1.00	1
47	Curcuma	1.00	1
48	cuscuta chinensis	1.00	1
49	cynomorium songaricum	1.00	1
50	dimocarpus longan	1.00	1

Showing top 50 of 153 compounds. Use the BiohacksAI search to explore all MAPK3 modulators.

About MAPK3 as a Drug Target

MAPK3 (mitogen-activated protein kinase 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 153 compounds with documented MAPK3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAPK3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.