RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REACTOME PATHWAYThe RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway (Reactome ID: R-HSA-73779) involves 2 genes and is affected by 4 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 2 | pictilisib | — | 25 |
| 3 | Sorafenib | — | 300 |
| 4 | Tripterygium | — | 300 |
About the RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Pathway
The RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway is catalogued in Reactome (ID: R-HSA-73779) and involves 2 genes. In the BiohacksAI corpus, 4 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, ERCC3.