What compounds affect the The NLRP1 inflammasome pathway?

16 compounds in the BiohacksAI corpus have documented interactions with genes in the The NLRP1 inflammasome pathway (Reactome ID: R-HSA-844455). These compounds target 2 genes within this pathway.

What genes are in the The NLRP1 inflammasome pathway?

The The NLRP1 inflammasome pathway involves 2 genes. Key genes include: BCL2L1, NLRP1.

The NLRP1 inflammasome

REACTOME PATHWAY

Reactome: R-HSA-8444552 genes16 compounds

The The NLRP1 inflammasome pathway (Reactome ID: R-HSA-844455) involves 2 genes and is affected by 16 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BCL2L1 NLRP1

Compounds Affecting The NLRP1 inflammasome

#	Compound	Targets Hit	Studies
1	paxilline	—	42
2	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
3	Anthralin	—	299
4	Aurintricarboxylic Acid	—	184
5	Domperidone	—	299
6	Metergoline	—	144
7	Masoprocol	—	300
8	Oxytetracycline	—	300
9	Tetracycline	—	300
10	vinblastine sulfate	—	81
11	Ethinyl Estradiol	—	300
12	Hexachlorophene	—	300
13	Thioridazine	—	35
14	Demeclocycline	—	5
15	Disulfiram	—	297
16	Norethynodrel	—	299

About the The NLRP1 inflammasome Pathway

The The NLRP1 inflammasome pathway is catalogued in Reactome (ID: R-HSA-844455) and involves 2 genes. In the BiohacksAI corpus, 16 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BCL2L1, NLRP1.