PTK6 Down-Regulation
REACTOME PATHWAYThe PTK6 Down-Regulation pathway (Reactome ID: R-HSA-8849472) involves 3 genes and is affected by 18 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting PTK6 Down-Regulation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dasatinib | — | 299 |
| 2 | Oleanolic Acid | — | 300 |
| 3 | Ursolic Acid | — | 300 |
| 4 | celastrol | — | 300 |
| 5 | Okadaic Acid | — | 300 |
| 6 | caffeic acid | — | 300 |
| 7 | Chlorogenic Acid | — | 300 |
| 8 | Methylene Blue | — | 200 |
| 9 | Oleic Acid | — | 112 |
| 10 | Mepentol [Supplementary Concept] | — | 184 |
| 11 | Evans Blue | — | 300 |
| 12 | Lithocholic Acid | — | 300 |
| 13 | Palmitic Acid | — | 300 |
| 14 | prunetin | — | 35 |
| 15 | Suramin | — | 300 |
| 16 | vanadates | — | 284 |
| 17 | Vemurafenib | — | 298 |
| 18 | Sorafenib | — | 300 |
About the PTK6 Down-Regulation Pathway
The PTK6 Down-Regulation pathway is catalogued in Reactome (ID: R-HSA-8849472) and involves 3 genes. In the BiohacksAI corpus, 18 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PTK6, PTPN1, SRMS.