What compounds affect the Synaptic adhesion-like molecules pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the Synaptic adhesion-like molecules pathway (Reactome ID: R-HSA-8849932). These compounds target 9 genes within this pathway.

What genes are in the Synaptic adhesion-like molecules pathway?

The Synaptic adhesion-like molecules pathway involves 9 genes. Key genes include: GRIA1, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, PTPRF, PTPRS.

Synaptic adhesion-like molecules

REACTOME PATHWAY

Reactome: R-HSA-88499329 genes26 compounds

The Synaptic adhesion-like molecules pathway (Reactome ID: R-HSA-8849932) involves 9 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GRIA1 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C PTPRF PTPRS

Compounds Affecting Synaptic adhesion-like molecules

#	Compound	Targets Hit	Studies
1	Glutamic Acid	—	297
2	Glutamic Acid	—	300
3	Glycine	—	300
4	pentamidine	—	299
5	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
6	Dextrorphan Dextro form of levorphanol. It acts as	—	300
7	Levorphanol	—	297
8	cycloserine	—	298
9	Aspartic Acid	—	300
10	D-Aspartic Acid	—	29
11	Ethidium	—	300
12	Dextrothyroxine	—	134
13	Dizocilpine Maleate	—	300
14	Ibotenic Acid	—	300
15	Spermine	—	300
16	eliprodil	—	33
17	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
18	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	—	300
19	Piracetam	—	300
20	aniracetam	—	110
21	Kynurenic Acid	—	300
22	Phenformin	—	300
23	Carvedilol	—	296
24	Ibogaine	—	300
25	Ursolic Acid	—	300
26	scutellarein	—	113

About the Synaptic adhesion-like molecules Pathway

The Synaptic adhesion-like molecules pathway is catalogued in Reactome (ID: R-HSA-8849932) and involves 9 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRIA1, GRIA3, GRIA4, GRIN1, GRIN2A.