Question 1

What compounds affect the FBXL7 down-regulates AURKA during mitotic entry and in early mitosis pathway?

Accepted Answer

24 compounds in the BiohacksAI corpus have documented interactions with genes in the FBXL7 down-regulates AURKA during mitotic entry and in early mitosis pathway (Reactome ID: R-HSA-8854050). These compounds target 35 genes within this pathway.

Question 2

What genes are in the FBXL7 down-regulates AURKA during mitotic entry and in early mitosis pathway?

Accepted Answer

The FBXL7 down-regulates AURKA during mitotic entry and in early mitosis pathway involves 35 genes. Key genes include: ADRM1, AURKA, CUL1, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7.

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
4	ninhydrin	—	300
5	Disulfiram	—	297
6	4-Hydroxybenzoate-3-Monooxygenase	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	chrysin	—	300
9	egcg	—	300
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Quercetin	—	300
12	Genistein	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Sorafenib	—	300
15	Crizotinib	—	298
16	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
17	Axitinib	—	298
18	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
19	kenpaullone	—	8
20	sp600125	—	117
21	candesartan cilexetil [Supplementary Concept]	—	300
22	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
23	Pioglitazone	—	297
24	Harmaline	—	300

BiohacksAI

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

Genes in this Pathway

Compounds Affecting FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

About the FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Pathway