VLDLR internalisation and degradation
REACTOME PATHWAYThe VLDLR internalisation and degradation pathway (Reactome ID: R-HSA-8866427) involves 2 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting VLDLR internalisation and degradation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Desmosterol | — | 300 |
| 2 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 3 | Hesperidin | — | 300 |
| 4 | Bosentan | — | 298 |
| 5 | piericidin | — | 32 |
| 6 | Progesterone | — | 299 |
| 7 | Gemfibrozil | — | 297 |
About the VLDLR internalisation and degradation Pathway
The VLDLR internalisation and degradation pathway is catalogued in Reactome (ID: R-HSA-8866427) and involves 2 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include NR1H2, NR1H3.