RAB geranylgeranylation
REACTOME PATHWAYThe RAB geranylgeranylation pathway (Reactome ID: R-HSA-8873719) involves 3 genes and is affected by 14 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RAB geranylgeranylation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Pueraria | — | 300 |
| 2 | Genistein | — | 300 |
| 3 | pterostilbene | — | 299 |
| 4 | amlexanox | — | 96 |
| 5 | kenpaullone | — | 8 |
| 6 | Leflunomide | — | 297 |
| 7 | Niclosamide | — | 299 |
| 8 | pd98059 | — | 7 |
| 9 | Phenelzine | — | 297 |
| 10 | Riluzole | — | 298 |
| 11 | tyrphostin ag 1295 | — | 1 |
| 12 | Guanosine Diphosphate | — | 300 |
| 13 | Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate). | — | 300 |
| 14 | pentamidine | — | 299 |
About the RAB geranylgeranylation Pathway
The RAB geranylgeranylation pathway is catalogued in Reactome (ID: R-HSA-8873719) and involves 3 genes. In the BiohacksAI corpus, 14 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PTP4A2, RAB7A, RAB9A.