GABA synthesis, release, reuptake and degradation
REACTOME PATHWAYThe GABA synthesis, release, reuptake and degradation pathway (Reactome ID: R-HSA-888590) involves 5 genes and is affected by 6 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting GABA synthesis, release, reuptake and degradation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | gamma-Aminobutyric Acid | — | 300 |
| 2 | Valproic Acid | — | 296 |
| 3 | Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate). | — | 300 |
| 4 | Hexachlorophene | — | 300 |
| 5 | Ergosterol | — | 300 |
| 6 | Tiagabine | — | 298 |
About the GABA synthesis, release, reuptake and degradation Pathway
The GABA synthesis, release, reuptake and degradation pathway is catalogued in Reactome (ID: R-HSA-888590) and involves 5 genes. In the BiohacksAI corpus, 6 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABAT, ALDH5A1, HSPA8, SLC6A11, SLC6A12.