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Evidence-Based Biohacking

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RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

REACTOME PATHWAY
Reactome: R-HSA-89392439 genes32 compounds

The RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known pathway (Reactome ID: R-HSA-8939243) involves 9 genes and is affected by 32 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CBFBCSNK2A1CSNK2A2CSNK2BEP300HIPK2PBRM1RUNX1SMARCA2

Compounds Affecting RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

#CompoundTargets HitStudies
1Luteolin 5,7,3',4'-tetrahydroxy-flavone,—150
2chrysin—300
3ly294002—11
4Apigenin 5,7,4'-trihydroxy-flavone,—300
5Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as—300
6Quercetin—300
7fisetin—78
8Kaempferols—300
9myricetin-3-O-galactopyranoside [Supplementary Concept]—300
10Vanillic Acid—300
11Disulfiram—297
12alsterpaullone—12
13kenpaullone—8
14sp600125—117
15pictilisib—25
16Aurintricarboxylic Acid—184
17Dihydroxyphenylalanine—300
18Ethidium—300
19juglone hydroxylase [Supplementary Concept] catalyzes—279
20Daunorubicin—298
21Fusaric Acid—300
22Harmaline—300
23Dichlororibofuranosylbenzimidazole—26
24Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.—300
25Axitinib—298
26Genistein—300
27calycosin—300
28Lovastatin—300
29Sorafenib—300
30plumbagin [Supplementary Concept]—300
31egcg—300
3211-hydroxypalmatine [Supplementary Concept]—238

About the RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Pathway

The RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known pathway is catalogued in Reactome (ID: R-HSA-8939243) and involves 9 genes. In the BiohacksAI corpus, 32 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CBFB, CSNK2A1, CSNK2A2, CSNK2B, EP300.