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BiohacksAI

Evidence-Based Biohacking

Patent Pending

Nucleotide biosynthesis

REACTOME PATHWAY
Reactome: R-HSA-89563205 genes5 compounds

The Nucleotide biosynthesis pathway (Reactome ID: R-HSA-8956320) involves 5 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATICDHODHGARTIMPDH1IMPDH2

Compounds Affecting Nucleotide biosynthesis

#CompoundTargets HitStudies
1Pemetrexed—299
2Methotrexate—289
3Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of—300
4Inosine Monophosphate Inosine 5'-Monophosphate.—299
5Leflunomide—297

About the Nucleotide biosynthesis Pathway

The Nucleotide biosynthesis pathway is catalogued in Reactome (ID: R-HSA-8956320) and involves 5 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATIC, DHODH, GART, IMPDH1, IMPDH2.