Interleukin-15 signaling
REACTOME PATHWAYThe Interleukin-15 signaling pathway (Reactome ID: R-HSA-8983432) involves 6 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Interleukin-15 signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Cefazolin | — | 300 |
| 3 | Methotrexate | — | 289 |
| 4 | Crizotinib | — | 298 |
| 5 | sp600125 | — | 117 |
| 6 | Axitinib | — | 298 |
| 7 | Niclosamide | — | 299 |
| 8 | Fingolimod Hydrochloride | — | 56 |
| 9 | Celecoxib | — | 295 |
| 10 | Dactinomycin | — | 297 |
About the Interleukin-15 signaling Pathway
The Interleukin-15 signaling pathway is catalogued in Reactome (ID: R-HSA-8983432) and involves 6 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, IL15, IL15RA, JAK3, STAT3.