Activated NTRK2 signals through CDK5
REACTOME PATHWAYThe Activated NTRK2 signals through CDK5 pathway (Reactome ID: R-HSA-9032845) involves 3 genes and is affected by 14 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Activated NTRK2 signals through CDK5
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | kenpaullone | — | 8 |
| 2 | alsterpaullone | — | 12 |
| 3 | indirubin | — | 300 |
| 4 | Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is | — | 300 |
| 5 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 6 | chrysin | — | 300 |
| 7 | fisetin | — | 78 |
| 8 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 9 | Sorafenib | — | 300 |
| 10 | egcg | — | 300 |
| 11 | sp600125 | — | 117 |
| 12 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 13 | Crizotinib | — | 298 |
| 14 | tyrosol | — | 300 |
About the Activated NTRK2 signals through CDK5 Pathway
The Activated NTRK2 signals through CDK5 pathway is catalogued in Reactome (ID: R-HSA-9032845) and involves 3 genes. In the BiohacksAI corpus, 14 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK5, CDK5R1, NTRK2.