RHOF GTPase cycle
REACTOME PATHWAYThe RHOF GTPase cycle pathway (Reactome ID: R-HSA-9035034) involves 4 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RHOF GTPase cycle
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | pictilisib | — | 25 |
| 2 | ly294002 | — | 11 |
| 3 | Sirolimus | — | 300 |
| 4 | Wortmannin | — | 300 |
| 5 | alpelisib | — | 227 |
| 6 | torin 1 | — | 10 |
| 7 | Quercetin | — | 300 |
| 8 | Ursolic Acid | — | 300 |
| 9 | streptonigrin | — | 299 |
| 10 | Ethylmaleimide | — | 300 |
| 11 | Guanosine Diphosphate | — | 300 |
| 12 | Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate). | — | 300 |
About the RHOF GTPase cycle Pathway
The RHOF GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9035034) and involves 4 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PIK3R1, PIK3R2, RAB7A, SENP1.