Negative regulators of DDX58/IFIH1 signaling
REACTOME PATHWAYThe Negative regulators of DDX58/IFIH1 signaling pathway (Reactome ID: R-HSA-936440) involves 3 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Negative regulators of DDX58/IFIH1 signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | amlexanox | — | 96 |
| 2 | Crizotinib | — | 298 |
| 3 | Axitinib | — | 298 |
| 4 | juglone hydroxylase [Supplementary Concept] catalyzes | — | 279 |
| 5 | Aurintricarboxylic Acid | — | 184 |
About the Negative regulators of DDX58/IFIH1 signaling Pathway
The Negative regulators of DDX58/IFIH1 signaling pathway is catalogued in Reactome (ID: R-HSA-936440) and involves 3 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IKBKE, PIN1, TBK1.