Ion transport by P-type ATPases
REACTOME PATHWAYThe Ion transport by P-type ATPases pathway (Reactome ID: R-HSA-936837) involves 16 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Ion transport by P-type ATPases
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. | — | 300 |
| 2 | Digoxin | — | 299 |
| 3 | Ouabain | — | 300 |
| 4 | Digitoxin | — | 300 |
| 5 | Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. | — | 300 |
| 6 | Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide. | — | 300 |
| 7 | KN 92 [Supplementary Concept] KN 93 isomer; | — | 26 |
| 8 | sp600125 | — | 117 |
| 9 | Cimetidine | — | 299 |
| 10 | paxilline | — | 42 |
| 11 | Deslanoside Deacetyllanatoside C. | — | 89 |
| 12 | Quercetin | — | 300 |
| 13 | Sorafenib | — | 300 |
| 14 | alsterpaullone | — | 12 |
| 15 | Thapsigargin | — | 300 |
About the Ion transport by P-type ATPases Pathway
The Ion transport by P-type ATPases pathway is catalogued in Reactome (ID: R-HSA-936837) and involves 16 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATP12A, ATP1A1, ATP1A2, ATP1A3, ATP1A4.