TRAF6-mediated induction of TAK1 complex within TLR4 complex
REACTOME PATHWAYThe TRAF6-mediated induction of TAK1 complex within TLR4 complex pathway (Reactome ID: R-HSA-937072) involves 2 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting TRAF6-mediated induction of TAK1 complex within TLR4 complex
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Adenosine | — | 298 |
| 3 | Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate). | — | 300 |
| 4 | Adenosine Triphosphate | — | 300 |
| 5 | Crizotinib | — | 298 |
| 6 | celastrol | — | 300 |
| 7 | Disulfiram | — | 297 |
About the TRAF6-mediated induction of TAK1 complex within TLR4 complex Pathway
The TRAF6-mediated induction of TAK1 complex within TLR4 complex pathway is catalogued in Reactome (ID: R-HSA-937072) and involves 2 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAP3K7, SARM1.