Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects
REACTOME PATHWAYThe Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects pathway (Reactome ID: R-HSA-9632693) involves 2 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | indirubin | — | 300 |
| 2 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 3 | chrysin | — | 300 |
| 4 | fisetin | — | 78 |
| 5 | Sorafenib | — | 300 |
About the Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects Pathway
The Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects pathway is catalogued in Reactome (ID: R-HSA-9632693) and involves 2 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK4, CDK6.