What compounds target CDK4?

BiohacksAI has identified 45 compounds that interact with CDK4 (cyclin dependent kinase 4). Top compounds include: seliciclib, alvocidib, palbociclib, ceritinib, bi 2536. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CDK4 (cyclin dependent kinase)?

CDK4 is cyclin dependent kinase 4. It is a molecular target for 45 compounds documented in PubMed bioassay data. UniProt ID: P11802. NCBI Gene ID: 1019.

CDK4

MOLECULAR TARGET

cyclin dependent kinase 4

UniProt: P11802 NCBI Gene: 101945 compounds

CDK4 (cyclin dependent kinase 4) is targeted by 45 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CDK4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	seliciclib	4.91	135
2	alvocidib	4.52	91
3	palbociclib	4.22	67
4	ceritinib	4.19	65
5	bi 2536	4.01	54
6	dinaciclib	3.87	47
7	abemaciclib	3.66	38
8	nintedanib	3.61	36
9	bms 387032	3.47	31
10	tae 684	3.43	30
11	fedratinib	3.40	29
12	gilteritinib	3.40	29
13	at 7519	3.33	27
14	dabrafenib	3.30	26
15	ribociclib	3.26	25
16	purvalanola	3.18	23
17	sulfuretin	3.14	22
18	dovitinib	3.09	21
19	at 9283	3.09	21
20	lestaurtinib	3.04	20
21	ruboxistaurin	2.94	18
22	k 252a	2.83	16
23	su 9516	2.83	16
24	milciclib	2.77	15
25	pha 665752	2.71	14
26	azd 5438	2.71	14
27	kw 2449	2.64	13
28	fascaplysin chloride	2.64	13
29	ast 487	2.56	12
30	roniciclib	2.56	12
31	su 014813	2.20	8
32	rebastinib	2.20	8
33	encorafenib	2.20	8
34	ct 7001	2.20	8
35	cyc 116	2.08	7
36	rg 547	2.08	7
37	zemirciclib	2.08	7
38	ebvaciclib	2.08	7
39	gw779439x	2.08	7
40	voruciclib	1.79	5
41	ly 2090314	1.79	5
42	bdb 5s 6r 7r 9r 16r 16 hydroxy 6 methoxy 5 methyl 7 methylamino 6 7 8 9 15 16 hexahy	1.39	3
43	indirubin	0.69	1
44	bdb pd 0183812 8 bicyclo 2 2 1 hept 2 yl 2 4 4 3 hydroxypropyl piperidin 1 yl phenyl	0.69	1
45	bdb pd0183812	0.69	1

About CDK4 as a Drug Target

CDK4 (cyclin dependent kinase 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 45 compounds with documented CDK4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CDK4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.