What compounds target CDK6?

BiohacksAI has identified 144 compounds that interact with CDK6 (cyclin dependent kinase 6). Top compounds include: seliciclib, alvocidib, palbociclib, dinaciclib, abemaciclib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CDK6 (cyclin dependent kinase)?

CDK6 is cyclin dependent kinase 6. It is a molecular target for 144 compounds documented in PubMed bioassay data. UniProt ID: Q00534. NCBI Gene ID: 1021.

CDK6

MOLECULAR TARGET

cyclin dependent kinase 6

UniProt: Q00534 NCBI Gene: 1021144 compounds

CDK6 (cyclin dependent kinase 6) is targeted by 144 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CDK6

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	seliciclib	4.91	135
2	alvocidib	4.52	91
3	palbociclib	4.22	67
4	dinaciclib	3.87	47
5	abemaciclib	3.66	38
6	bms 387032	3.47	31
7	at 7519	3.33	27
8	dabrafenib	3.30	26
9	ribociclib	3.26	25
10	sulfuretin	3.14	22
11	dovitinib	3.09	21
12	at 9283	3.09	21
13	lestaurtinib	3.04	20
14	momelotinib	2.89	17
15	k 252a	2.83	16
16	milciclib	2.77	15
17	azd 5438	2.71	14
18	fascaplysin chloride	2.64	13
19	zotiraciclib	2.56	12
20	ct 7001	2.20	8
21	cyc 116	2.08	7
22	rg 547	2.08	7
23	zemirciclib	2.08	7
24	ebvaciclib	2.08	7
25	pf 03814735	1.79	5
26	voruciclib	1.79	5
27	Apigenin 5,7,4'-trihydroxy-flavone,	1.39	3
28	chrysin	1.39	3
29	fisetin	1.39	3
30	achyranthes bidentata	1.00	1
31	agastache rugosa	1.00	1
32	Garlic	1.00	1
33	aloe vera	1.00	1
34	arctium lappa	1.00	1
35	artemisia argyi	1.00	1
36	artemisia capillaris	1.00	1
37	aster tataricus	1.00	1
38	atractylodes macrocephala	1.00	1
39	bombyx mori	1.00	1
40	bufo bufo	1.00	1
41	carthamus tinctorius	1.00	1
42	Centella	1.00	1
43	chaenomeles speciosa	1.00	1
44	citrus reticulata	1.00	1
45	crataegus pinnatifida	1.00	1
46	curculigo orchioides	1.00	1
47	Curcuma	1.00	1
48	cuscuta chinensis	1.00	1
49	cynomorium songaricum	1.00	1
50	ephedra sinica	1.00	1

Showing top 50 of 144 compounds. Use the BiohacksAI search to explore all CDK6 modulators.

About CDK6 as a Drug Target

CDK6 (cyclin dependent kinase 6) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 144 compounds with documented CDK6 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CDK6 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.