TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
REACTOME PATHWAYThe TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway (Reactome ID: R-HSA-975110) involves 4 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | naringin | — | 300 |
| 2 | Chlorhexidine | — | 299 |
| 3 | Perphenazine | — | 297 |
| 4 | Sphingosine | — | 300 |
| 5 | Resveratrol | — | 298 |
| 6 | Sertraline | — | 1,000 |
| 7 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 8 | Canrenone | — | 300 |
| 9 | Thioridazine | — | 35 |
| 10 | Crizotinib | — | 298 |
| 11 | Afatinib | — | 297 |
| 12 | alsterpaullone | — | 12 |
| 13 | Axitinib | — | 298 |
| 14 | Sorafenib | — | 300 |
| 15 | Dasatinib | — | 299 |
| 16 | sp600125 | — | 117 |
| 17 | Oxyphenbutazone | — | 300 |
About the TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Pathway
The TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway is catalogued in Reactome (ID: R-HSA-975110) and involves 4 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IRAK1, IRAK4, TLR9, UBE2N.