Question 1

What compounds affect the SARS-CoV-2 modulates host translation machinery pathway?

Accepted Answer

19 compounds in the BiohacksAI corpus have documented interactions with genes in the SARS-CoV-2 modulates host translation machinery pathway (Reactome ID: R-HSA-9754678). These compounds target 3 genes within this pathway.

Question 2

What genes are in the SARS-CoV-2 modulates host translation machinery pathway?

Accepted Answer

The SARS-CoV-2 modulates host translation machinery pathway involves 3 genes. Key genes include: RPSA, SMN1, SMN2.

#	Compound	Targets Hit	Studies
1	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
2	Niclosamide	—	299
3	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
4	Leflunomide	—	297
5	Pueraria	—	300
6	Genistein	—	300
7	Resveratrol	—	298
8	pd98059	—	7
9	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	Bromodeoxyuridine	—	300
12	kenpaullone	—	8
13	chrysin	—	300
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	Azauridine	—	300
16	Lovastatin	—	300
17	piceatannol	—	300
18	tyrphostin ag 1295	—	1
19	egcg	—	300

BiohacksAI

SARS-CoV-2 modulates host translation machinery

Genes in this Pathway

Compounds Affecting SARS-CoV-2 modulates host translation machinery

About the SARS-CoV-2 modulates host translation machinery Pathway