Question 1

What compounds affect the Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK pathway?

Accepted Answer

20 compounds in the BiohacksAI corpus have documented interactions with genes in the Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK pathway (Reactome ID: R-HSA-9931529). These compounds target 3 genes within this pathway.

Question 2

What genes are in the Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK pathway?

Accepted Answer

The Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK pathway involves 3 genes. Key genes include: CDK5, CSNK2A1, CSNK2B.

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	fisetin	—	78
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	chrysin	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Quercetin	—	300
7	Kaempferols	—	300
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	Vanillic Acid	—	300
10	ly294002	—	11
11	alsterpaullone	—	12
12	kenpaullone	—	8
13	sp600125	—	117
14	Dichlororibofuranosylbenzimidazole	—	26
15	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
16	indirubin	—	300
17	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
18	hydroxyfasudil [Supplementary Concept]	—	11
19	Sorafenib	—	300
20	egcg	—	300

BiohacksAI

Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK

Genes in this Pathway

Compounds Affecting Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK

About the Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Pathway