Degradation of CRY and PER proteins
REACTOME PATHWAYThe Degradation of CRY and PER proteins pathway (Reactome ID: R-HSA-9932298) involves 34 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Degradation of CRY and PER proteins
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bortezomib | — | 300 |
| 2 | Reserpine | — | 297 |
| 3 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 4 | ninhydrin | — | 300 |
| 5 | Disulfiram | — | 297 |
| 6 | 4-Hydroxybenzoate-3-Monooxygenase | — | 300 |
| 7 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 8 | chrysin | — | 300 |
| 9 | egcg | — | 300 |
| 10 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 11 | Quercetin | — | 300 |
| 12 | Genistein | — | 300 |
| 13 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 14 | candesartan cilexetil [Supplementary Concept] | — | 300 |
| 15 | Cetylpyridinium Cationic bactericidal surfactant used as | — | 300 |
| 16 | Pioglitazone | — | 297 |
| 17 | Harmaline | — | 300 |
About the Degradation of CRY and PER proteins Pathway
The Degradation of CRY and PER proteins pathway is catalogued in Reactome (ID: R-HSA-9932298) and involves 34 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CUL1, PSMA1, PSMA2, PSMA3.