What compounds affect the GBP-mediated host defense pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the GBP-mediated host defense pathway (Reactome ID: R-HSA-9953170). These compounds target 7 genes within this pathway.

What genes are in the GBP-mediated host defense pathway?

The GBP-mediated host defense pathway involves 7 genes. Key genes include: CASP1, CHURC1-FNTB, FNTA, FNTB, FURIN, PGGT1B, PIM1.

GBP-mediated host defense

REACTOME PATHWAY

Reactome: R-HSA-99531707 genes26 compounds

The GBP-mediated host defense pathway (Reactome ID: R-HSA-9953170) involves 7 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP1 CHURC1-FNTB FNTA FNTB FURIN PGGT1B PIM1

Compounds Affecting GBP-mediated host defense

#	Compound	Targets Hit	Studies
1	Lovastatin	—	300
2	Gliotoxin	—	300
3	Quercetin	—	300
4	ly294002	—	11
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
7	kenpaullone	—	8
8	sp600125	—	117
9	fisetin	—	78
10	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
11	Kaempferols	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	alsterpaullone	—	12
14	Colchicine	—	300
15	piceatannol	—	300
16	cbd	—	298
17	Dehydroepiandrosterone Sulfate	—	300
18	cannabidiol	—	296
19	Disulfiram	—	297
20	Ethinyl Estradiol	—	300
21	Hexachlorophene	—	300
22	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
23	Norethynodrel	—	299
24	Thioridazine	—	35
25	Diminazene	—	300
26	silver sulfadiazine	—	299

About the GBP-mediated host defense Pathway

The GBP-mediated host defense pathway is catalogued in Reactome (ID: R-HSA-9953170) and involves 7 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP1, CHURC1-FNTB, FNTA, FNTB, FURIN.