Regulation of GBP-mediated host defense
REACTOME PATHWAYThe Regulation of GBP-mediated host defense pathway (Reactome ID: R-HSA-9968551) involves 2 genes and is affected by 22 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Regulation of GBP-mediated host defense
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Quercetin | — | 300 |
| 2 | ly294002 | — | 11 |
| 3 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 4 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 5 | kenpaullone | — | 8 |
| 6 | sp600125 | — | 117 |
| 7 | fisetin | — | 78 |
| 8 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 9 | Kaempferols | — | 300 |
| 10 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 11 | alsterpaullone | — | 12 |
| 12 | Colchicine | — | 300 |
| 13 | piceatannol | — | 300 |
| 14 | cbd | — | 298 |
| 15 | Dehydroepiandrosterone Sulfate | — | 300 |
| 16 | cannabidiol | — | 296 |
| 17 | Disulfiram | — | 297 |
| 18 | Ethinyl Estradiol | — | 300 |
| 19 | Hexachlorophene | — | 300 |
| 20 | juglone hydroxylase [Supplementary Concept] catalyzes | — | 279 |
| 21 | Norethynodrel | — | 299 |
| 22 | Thioridazine | — | 35 |
About the Regulation of GBP-mediated host defense Pathway
The Regulation of GBP-mediated host defense pathway is catalogued in Reactome (ID: R-HSA-9968551) and involves 2 genes. In the BiohacksAI corpus, 22 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP1, PIM1.