Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REACTOME PATHWAYThe Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway (Reactome ID: R-HSA-997272) involves 4 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | gamma-Aminobutyric Acid | — | 300 |
| 2 | Arachidonic Acid | — | 245 |
| 3 | Spermidine | — | 241 |
| 4 | Putrescine | — | 300 |
| 5 | SCH 23390 [Supplementary Concept] | — | 126 |
| 6 | Spermine | — | 300 |
| 7 | Nortriptyline | — | 295 |
About the Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Pathway
The Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway is catalogued in Reactome (ID: R-HSA-997272) and involves 4 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GABBR1, GABBR2, KCNJ10, KCNJ4.