A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
Spermidine has been studied across 24 research domains including ⏳ Longevity & Aging, 🔬 Oncology, 🔬 Inflammation, 🧘 Stress & Anxiety, 🦠 Gut & Microbiome. The primary research focus is ⏳ Longevity & Aging with 40% of studies addressing this area.
The following compounds share molecular targets with Spermidine, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.
This evidence profile for Spermidine is generated deterministically from 428 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.